What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

N‐acetylcysteine (1200 mg) vs placebo

Acute chest syndrome ( · sickle cell disease

It is very uncertain whether N‐acetylcysteine (1200 mg) changes frequency of sickle cell‐related complications (acute chest syndrome) compared with placebo (very low certainty).

1 finding from 1 review

Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
RR 5 [0.25, 101.48]
1 study · 96 participants
Very low

Vitamin C 1400 mg plus vitamin E 800 mg vs placebo

Acute chest syndrome ( · adults with sickle cell disease (adults with homozygous SCA or sickle beta 0 thalassaemia SCD)

It is very uncertain whether vitamin C 1400 mg plus vitamin E 800 mg changes frequency of sickle cell‐related complications: acute chest syndrome compared with placebo (very low certainty).

1 finding from 1 review

Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
RR 2.66
1 study · 83 participants
Very low