Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

7 questions · 7 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 7 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Vitamin D compounds (supplementation) vs placebo or control

Fracture · Adults with chronic kidney disease requiring dialysis

Meta-analysis of randomised trials of vitamin D supplementation for Fractures: RR 1.00 (95% CI 0.06 to 15.41), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Vitamin D vs placebo or control

Fracture · Older or community-dwelling adults

Meta-analysis of randomised trials of vitamin D supplementation for Fractures, Men aged >65 years and postmenopausal women: RR 1.01 (95% CI 0.93 to 1.09), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

Fracture · Participants in observational studies

The meta-analysis of observational studies reported a SMD (to OR) of 0.31 (95% CI 0.23 to 0.42) for higher versus lower circulating vitamin D concentration.

1 finding from 1 review

Vitamin D vs placebo or control

Hip Fracture · Older or community-dwelling adults

Meta-analysis of randomised trials of vitamin D supplementation for Fractures: hip, Men aged >65 years and postmenopausal women: RR 1.15 (95% CI 0.99 to 1.33), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Vitamin D vs placebo or control

Non‐vertebral fractures · Older or community-dwelling adults

Meta-analysis of randomised trials of vitamin D supplementation for Fractures: non-vertebral, People aged >65 years: RR 0.79 (95% CI 0.63 to 0.99), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

1 finding from 1 review

Vitamin D vs placebo or control

Fractures: non-vertebral, non-hip · Older or community-dwelling adults

Meta-analysis of randomised trials of vitamin D supplementation for Fractures: non-vertebral, non-hip, Older women: OR 0.69 (95% CI 0.21 to 1.66), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Vitamin D vs placebo or control

Fractures: vertebral or deformity · Older or community-dwelling adults

Meta-analysis of randomised trials of vitamin D supplementation for Fractures: vertebral or deformity, Men aged >65 years and postmenopausal women: RR 0.90 (95% CI 0.42 to 1.92), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review