What do systematic reviews say?

Paroxetine vs reboxetine

Paroxetine probably leads to lower failure to respond at 1‐4 weeks compared with reboxetine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.66 [0.5, 0.87]
  3 studies · 1375 participants
  Moderate

Paroxetine vs sertraline

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs tianeptine

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs trazodone

Paroxetine showed no clear difference in failure to respond at 1‐4 weeks compared with trazodone (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.54 [0.25, 1.19]
  1 study · 108 participants
  Moderate

Paroxetine vs venlafaxine

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs AMISULPRIDE

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs older ADs

Paroxetine showed no clear difference in failure to respond at 1‐4 weeks compared with older ADs (low certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.9 [0.61, 1.33]
  4 studies · 526 participants
  Low

Paroxetine vs aprepitant

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs bupropion

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs citalopram

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs duloxetine

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs escitalopram

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs fluoxetine

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs fluvoxamine

Paroxetine showed no clear difference in failure to respond at 1‐4 weeks compared with fluvoxamine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.71 [0.41, 1.24]
  3 studies · 281 participants
  Moderate

Paroxetine vs hypericum

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs milnacipran

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs mirtazapine

Paroxetine probably leads to higher failure to respond at 1‐4 weeks compared with mirtazapine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 2.39 [1.42, 4.02]
  3 studies · 726 participants
  Moderate

Paroxetine vs agomelatine

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs nefazodone

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported