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Evidence found and GRADE certainty

3 questions · 4 findings · 1 reviews

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No studies found 1 · 25%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 25%Moderate 2 · 50%High 0 · 0%

Two infusions of natalizumab (6 mg/kg) vs placebo

Failure to induce clinical response (Panaccione 2010) CDAI ‐ (≥100 point reduction) · Patients with active Crohn's disease

Two infusions of natalizumab (6 mg/kg) showed no clear difference in failure to induce clinical response at 6 weeks compared with placebo (moderate certainty).

2 findings from 1 review

Two infusions of natalizumab (300 mg or 3 mg/kg) vs placebo

Failure to induce clinical response (Panaccione 2010) CDAI ‐ (≥100 point reduction) · Patients with active Crohn's disease

Two infusions of natalizumab (300 mg or 3 mg/kg) showed no clear difference in failure to induce clinical response at 6 weeks compared with placebo (low certainty).

1 finding from 1 review