Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Gut

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 2 · 100%

Failure to induce clinical response (Panaccione 2010) CDAI ‐ (≥100 point reduction) · induction of remission in Crohn's disease

Ustekinumab leads to lower failure to induce clinical response CDAI (≥100 point reduction) compared with placebo (high certainty).

1 finding from 1 review

Anti‐IL‐12/23p40 antibodies for induction of remission in Crohn's disease 2016 · Cochrane Headline outcomes only
RR 0.82 [0.77, 0.88]
3 studies · 1320 participants
High

Failure to induce clinical response (6 mg/kg subgroup) CDAI (≥100 point reduction) · induction of remission in Crohn's disease

Ustekinumab leads to lower failure to induce clinical response (6 mg/kg subgroup) CDAI (≥100… compared with placebo (high certainty).

1 finding from 1 review

Anti‐IL‐12/23p40 antibodies for induction of remission in Crohn's disease 2016 · Cochrane Headline outcomes only
RR 0.83 [0.77, 0.91]
2 studies · 916 participants
High