What do systematic reviews say?

Fluoxetine vs ABT‐200

Fluoxetine may leads to lower failure to complete ‐ side effects ‐ compared with ABT‐200 (low certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.08 [0.02, 0.27]
  1 study · 144 participants
  Low

Fluoxetine vs phenelzine

It is very uncertain whether fluoxetine changes failure to complete ‐ side effects ‐ compared with phenelzine (very low certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.32 [0.01, 8.26]
  1 study · 40 participants
  Very low

Fluoxetine vs pramipexole

Fluoxetine may leads to lower failure to complete ‐ side effects ‐ compared with pramipexole (low certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.06 [0.01, 0.5]
  1 study · 105 participants
  Low

Fluoxetine vs reboxetine

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with reboxetine (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.41 [0.15, 1.09]
  2 studies · 211 participants
  Moderate

Fluoxetine vs sertraline

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with sertraline (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.25 [0.92, 1.7]
  9 studies · 1591 participants
  Moderate

Fluoxetine vs tianeptine

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with tianeptine (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.13 [0.71, 1.8]
  3 studies · 830 participants
  Moderate

Fluoxetine vs trazodone

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with trazodone (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.66 [0.2, 2.19]
  3 studies · 110 participants
  Moderate

Fluoxetine vs venlafaxine

Fluoxetine probably leads to lower failure to complete ‐ side effects ‐ compared with venlafaxine (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.72 [0.56, 0.94]
  13 studies · 2640 participants
  Moderate

Fluoxetine vs agomelatine

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with agomelatine (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.51 [0.74, 3.07]
  2 studies · 785 participants
  Moderate

Fluoxetine vs AMISULPRIDE

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with amisulpride (low certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.77 [0.33, 1.82]
  1 study · 281 participants
  Low

Fluoxetine vs bupropion

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with bupropion (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.01 [0.45, 2.25]
  2 studies · 436 participants
  Moderate

Fluoxetine vs citalopram

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with citalopram (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.64 [0.34, 1.2]
  3 studies · 732 participants
  Moderate

Fluoxetine vs tricyclic antidepressants (TCAs)

Fluoxetine probably leads to lower failure to complete ‐ side effects ‐ compared with TCAs (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.55 [0.4, 0.75]
  40 studies · 3647 participants
  Moderate

Fluoxetine vs Crocus sativus

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Fluoxetine vs duloxetine

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with duloxetine (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.28 [0.07, 1.23]
  2 studies · 532 participants
  Moderate

Fluoxetine vs escitalopram

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with escitalopram (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.17 [0.64, 2.12]
  2 studies · 578 participants
  Moderate

Fluoxetine vs fluvoxamine

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with fluvoxamine (low certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.04 [0.14, 7.71]
  1 study · 100 participants
  Low

Fluoxetine vs hypericum

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with hypericum (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.21 [0.56, 2.64]
  5 studies · 679 participants
  Moderate

Fluoxetine vs maprotiline

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with maprotiline (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.53 [0.15, 1.93]
  3 studies · 209 participants
  Moderate

Fluoxetine vs mianserin

It is very uncertain whether fluoxetine changes failure to complete ‐ side effects ‐ compared with mianserin (very low certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.05 [0.23, 4.7]
  1 study · 53 participants
  Very low