What do systematic reviews say?

Fluoxetine vs mirtazapine

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with mirtazapine (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 1.45 [0.71, 2.96]
  4 studies · 600 participants
  Moderate

Fluoxetine vs moclobemide

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with moclobemide (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.7 [0.32, 1.56]
  6 studies · 679 participants
  Moderate

Fluoxetine vs nefazodone

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with nefazodone (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.71 [0.05, 10.71]
  3 studies · 161 participants
  Moderate

Fluoxetine vs ABT‐200

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with ABT‐200 (low certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.24 [0.03, 2.2]
  1 study · 144 participants
  Low

Fluoxetine vs paroxetine

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with paroxetine (moderate certainty).

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  OR 0.75 [0.41, 1.39]
  4 studies · 1005 participants
  Moderate

Fluoxetine vs phenelzine

• Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported