What do systematic reviews say?

Paroxetine vs reboxetine

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with reboxetine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.78 [0.51, 1.19]
  3 studies · 1375 participants
  Moderate

Paroxetine vs sertraline

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with sertraline (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.37 [0.52, 3.6]
  2 studies · 426 participants
  Moderate

Paroxetine vs tianeptine

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with tianeptine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.46 [0.75, 2.85]
  3 studies · 648 participants
  Moderate

Paroxetine vs trazodone

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs agomelatine

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with agomelatine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.99 [0.57, 1.71]
  1 study · 284 participants
  Moderate

Paroxetine vs venlafaxine

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with venlafaxine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.08 [0.82, 1.44]
  6 studies · 1079 participants
  Moderate

Paroxetine vs AMISULPRIDE

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Paroxetine vs aprepitant

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with aprepitant (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.53 [0.76, 3.09]
  1 study · 143 participants
  Moderate

Paroxetine vs bupropion

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with bupropion (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.16 [0.62, 2.2]
  2 studies · 240 participants
  Moderate

Paroxetine vs citalopram

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with citalopram (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.99 [0.61, 1.6]
  1 study · 406 participants
  Moderate

Paroxetine vs duloxetine

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with duloxetine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.97 [0.77, 1.23]
  6 studies · 1821 participants
  Moderate

Paroxetine vs escitalopram

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with escitalopram (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.47 [0.77, 2.79]
  2 studies · 784 participants
  Moderate

Paroxetine vs older ADs

Paroxetine probably leads to lower failure to complete ‐ any cause ‐ compared with older ADs (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.84 [0.73, 0.96]
  44 studies · 6810 participants
  Moderate

Paroxetine vs fluvoxamine

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with fluvoxamine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.96 [0.54, 1.72]
  3 studies · 261 participants
  Moderate

Paroxetine vs hypericum

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with hypericum (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.9 [0.98, 3.67]
  1 study · 251 participants
  Moderate

Paroxetine vs milnacipran

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with milnacipran (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.17 [0.67, 2.3]
  2 studies · 343 participants
  Moderate

Paroxetine vs mirtazapine

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with mirtazapine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.26 [0.91, 1.74]
  3 studies · 726 participants
  Moderate

Paroxetine vs nefazodone

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with nefazodone (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 0.53 [0.11, 2.6]
  1 study · 40 participants
  Moderate

Paroxetine vs fluoxetine

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ total drop out rate compared with fluoxetine (moderate certainty).

• Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
  OR 1.05 [0.89, 1.23]
  13 studies · 2798 participants
  Moderate