What do systematic reviews say?

Tiotropium + LABA/ICS combination vs tiotropium

Tiotropium + LABA/ICS combination showed no clear difference in exacerbation ‐ at 12‐month compared with tiotropium (low certainty).

• Combination inhaled steroid and long‐acting beta₂‐agonist in addition to tiotropium versus tiotropium or combination… 2016 · Cochrane Headline outcomes only
  OR 0.89 [0.56, 1.41]
  1 study · 301 participants
  Low