Findings

What do systematic reviews say?

5 questions · 5 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 60%Low 2 · 40%Moderate 0 · 0%High 0 · 0%

Ketamine vs placebo

Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults (aged 18 years+) with depression in bipolar disorder

Ketamine may leads to higher efficacy: number of participants who respond to treatment ‐ at 24… compared with placebo (low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
OR 11.61 [1.25, 107.74]
2 studies · 33 participants
Low

Ketamine vs midazolam

Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults (aged 18 years+) with depression in bipolar disorder

It is very uncertain whether ketamine changes efficacy: number of participants who respond to treatment ‐ at 24… compared with midazolam (very low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
OR 3.2 [0.23, 45.19]
1 study · 16 participants
Very low

Ketamine vs midazolam

Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults with Major Depressive Disorder

It is very uncertain whether ketamine changes efficacy: number of participants who respond to treatment ‐ at 24… compared with midazolam (very low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
OR 2.48 [1, 6.18]
Studies not reported
Very low

Ketamine vs placebo

Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults with Major Depressive Disorder

It is very uncertain whether ketamine changes efficacy: number of participants who respond to treatment ‐ at 24… compared with placebo (very low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
OR 3.94 [1.54, 10.1]
Studies not reported
Very low

Esketamine vs placebo

Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults with Major Depressive Disorder

Esketamine may leads to higher efficacy: number of participants who respond to treatment ‐ at 24… compared with placebo (low certainty).

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder 2021 · Cochrane Headline outcomes only
OR 2.11 [1.2, 3.68]
Studies not reported
Low