Findings

What do systematic reviews say?

1 questions · 1 findings · 1 reviews · Drugs and Alcohol

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 100%Moderate 0 · 0%High 0 · 0%

Adverse effects (drop‐outs due to adverse effects4) · People undergoing managed opioid withdrawal

Alpha2‐adrenergic agonist showed no clear difference in drop‐out due to adverse effects compared with methadone (low certainty).

1 finding from 1 review

Alpha₂‐adrenergic agonists for the management of opioid withdrawal 2016 · Cochrane Headline outcomes only
RR 3.62 [0.77, 16.94]
4 studies · 153 participants
Low