Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

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No studies found 4 · 66.7%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%

Aldosterone antagonists vs diuretics

Doubling serum creatinine · proteinuric CKD

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Aldosterone antagonists vs calcium channel blockers

Doubling serum creatinine · proteinuric CKD

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Aldosterone antagonists vs ACEi or ACEi plus ARB

Doubling serum creatinine · proteinuric chronic kidney disease

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Aldosterone antagonists vs placebo or usual care

Doubling serum creatinine · proteinuric CKD

Aldosterone antagonists showed no clear difference in doubling serum creatinine compared with placebo or standard care (low certainty).

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
RR 1.3 [0.69, 2.44]
2 studies · 875 participants
Low

Aldosterone antagonists vs nitrate

Doubling serum creatinine · proteinuric chronic kidney disease

The review found no eligible studies for this question.

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

Doubling serum creatinine · proteinuric chronic kidney disease

Non‐steroidal mineralocorticoid receptor antagonist showed no clear difference in doubling serum creatinine compared with selective aldosterone antagonist (low certainty).

1 finding from 1 review

Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic… 2020 · Cochrane Headline outcomes only
RR 0.8 [0.03, 19.51]
1 study · 1055 participants
Low