Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Epilepsy

No studies found 0 · 0%GRADE not reported 2 · 33.3%Very low 0 · 0%Low 3 · 50%Moderate 1 · 16.7%High 0 · 0%

> 50% reduction in depressive symptoms · people with epilepsy and depression

Paroxetine showed no clear difference in > 50% reduction in depressive symptoms compared with doxepin (moderate certainty).

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
RR 1.16 [0.88, 1.52]
1 study · 67 participants
Moderate

> 50% reduction in depressive symptoms · people with epilepsy and depression

Venlafaxine may leads to higher > 50% reduction in depressive symptoms compared with no treatment (low certainty).

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
RR 3.25 [1.19, 8.9]
1 study · 64 participants
Low

> 50% reduction in depressive symptoms · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

> 50% reduction in depressive symptoms · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
45 participants
Low

> 50% reduction in depressive symptoms · people with epilepsy and depression

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

> 50% reduction in depressive symptoms · people with epilepsy and depression

Amitriptyline showed no clear difference in > 50% reduction in depressive symptoms compared with nomifensine (low certainty).

1 finding from 1 review

Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
RR 0.55 [0.28, 1.06]
1 study · 28 participants
Low