Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

10 questions · 11 findings · 5 reviews · Oral Health

No studies found 0 · 0%GRADE not reported 8 · 72.7%Very low 3 · 27.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Depression · People with temporomandibular disorders (TMD)

Occlusal splint showed no clear difference in depression compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.

1 finding from 1 review

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

Depression · Adults (general population)

Meta-analysis of observational studies (higher vs lower 25(OH)D) for Depression (Cohort studies): HR 0.44 (95% CI 0.27 to 0.72), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

2 findings from 1 review

Psychosocial interventions (cognitive behavioural therapy, biofeedback, combination CBT/biofeedback, physical self-regulation/posture self-control) vs usual care

Depression (long term) · Adults over 18 years of age with chronic orofacial pain (temporomandibular disorder (TMD))

Psychosocial interventions (cognitive behavioural therapy,… led to lower depression (long term) compared with usual care (conservative treatment: education, counselling,…; GRADE not reported.

1 finding from 1 review

Benzodiazepines (systemic clonazepam) vs placebo

Change in QoL - depression (surrogate marker) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether benzodiazepines (systemic clonazepam) changes change in QoL - depression (surrogate marker) compared with placebo (very low certainty).

1 finding from 1 review

Dietary supplements (lycopene) vs placebo

Change in QoL - depression (surrogate marker) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether dietary supplements (lycopene) changes change in QoL - depression (surrogate marker) compared with placebo (very low certainty).

1 finding from 1 review

Physical barriers (tongue protector) vs placebo

Change in QoL - depression (surrogate marker) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether physical barriers (tongue protector) changes change in QoL - depression (surrogate marker) compared with placebo (very low certainty).

1 finding from 1 review