Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 100%Moderate 0 · 0%High 0 · 0%

Summary of findings ‐ initiation of penicillin prophylaxis vs placebo

Deaths · children with SCD

Summary of findings ‐ initiation of penicillin prophylaxis showed no clear difference in deaths compared with placebo (low certainty).

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
OR 0.11 [0.01, 2.11]
2 studies · 457 participants
Low

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Deaths · children with SCD who have been receiving prophylactic penicillin for at least two years

1 finding from 1 review

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 400 participants
Low