Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews

No studies found 1 · 25%GRADE not reported 0 · 0%Very low 1 · 25%Low 1 · 25%Moderate 1 · 25%High 0 · 0%

Death at hospital discharge · preterm infants at risk for apnea

It is very uncertain whether methylxanthine changes death at hospital discharge compared with placebo or control (very low certainty).

1 finding from 1 review

Methylxanthine for the prevention and treatment of apnea in preterm infants 2023 · Cochrane Headline outcomes only
RR 2.19 [0.85, 5.68]
3 studies · 129 participants
Very low

Death at hospital discharge · preterm infants with apnea

Methylxanthine showed no clear difference in death at hospital discharge compared with placebo or control (low certainty).

1 finding from 1 review

Methylxanthine for the prevention and treatment of apnea in preterm infants 2023 · Cochrane Headline outcomes only
RR 0.49 [0.14, 1.78]
3 studies · 154 participants
Low

Death at hospital discharge · preterm infants at risk of or with apnea; preterm infants undergoing extubation

Methylxanthine showed no clear difference in death at hospital discharge compared with placebo or control (moderate certainty).

1 finding from 1 review

Methylxanthine for the prevention and treatment of apnea in preterm infants 2023 · Cochrane Headline outcomes only
RR 0.99 [0.71, 1.37]
7 studies · 2289 participants
Moderate

Death at hospital discharge · preterm infants prior to extubation

The review found no eligible studies for this question.

1 finding from 1 review

Methylxanthine for the prevention and treatment of apnea in preterm infants 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found