Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Heart

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 33.3%High 2 · 66.7%

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in death by any cause compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

Homocysteine‐lowering interventions for preventing cardiovascular events 2017 · Cochrane Headline outcomes only
RR 0.86 [0.66, 1.11]
1 study · 3649 participants
Moderate

Homocysteine‐lowering interventions (Folic Acid, Vitamin B6 and Vitamin B12) vs placebo or usual care

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (Vitamin B6 (pyridoxine;… showed no clear difference in death by any cause compared with placebo or standard care (high certainty).

1 finding from 1 review

Homocysteine‐lowering interventions for preventing cardiovascular events 2017 · Cochrane Headline outcomes only
RR 1.01 [0.96, 1.06]
11 studies · 44817 participants
High

Enalapril plus folic acid vs enalapril

Death from any cause · patients with hypertension

Enalapril plus folic acid showed no clear difference in death from any cause compared with enalapril (high certainty).

1 finding from 1 review

Homocysteine‐lowering interventions for preventing cardiovascular events 2017 · Cochrane Headline outcomes only
RR 0.94 [0.81, 1.1]
1 study · 20702 participants
High