Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 3 · 75%Moderate 0 · 0%High 0 · 0%

Isoniazid prophylaxis vs placebo

Death · HIV‐positive children not taking ART

Isoniazid prophylaxis may leads to lower death compared with placebo (low certainty).

1 finding from 1 review

Isoniazid for preventing tuberculosis in HIV‐infected children 2017 · Cochrane Headline outcomes only
HR 0.46 [0.22, 0.95]
1 study · 240 participants
Low

Isoniazid prophylaxis vs placebo

Death · Children living with HIV receiving ART

It is very uncertain whether isoniazid prophylaxis changes death compared with placebo (very low certainty).

1 finding from 1 review

Isoniazid for preventing tuberculosis in HIV‐infected children 2017 · Cochrane Headline outcomes only
RR 1.45 [0.78, 2.72]
3 studies · 737 participants
Very low

Fluoroquinolone substitution for isoniazid in a standard six month regimen vs standard regimen

TB‐related death · Patients with presumed drug‐sensitive TB

Fluoroquinolone substitution for isoniazid in a standard six month… showed no clear difference in TB‐related death compared with standard regimen (low certainty).

1 finding from 1 review

Fluoroquinolones for treating tuberculosis (presumed drug‐sensitive) 2013 · Cochrane Headline outcomes only
RR 2 [0.18, 21.84]
1 study · 433 participants
Low

Fluoroquinolone substitution for isoniazid in a standard six month regimen vs standard regimen

Death from any cause · Patients with presumed drug‐sensitive TB

Fluoroquinolone substitution for isoniazid in a standard six month… showed no clear difference in death from any cause compared with standard regimen (low certainty).

1 finding from 1 review

Fluoroquinolones for treating tuberculosis (presumed drug‐sensitive) 2013 · Cochrane Headline outcomes only
RR 0.75 [0.17, 3.3]
1 study · 433 participants
Low