Findings

What do systematic reviews say?

4 questions · 5 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 3 · 60%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 2 · 40%

Artesunate vs Quinine

Death · Patients with severe malaria

The fixed-effect NMR reported a difference between artesunate and quinine at every displayed average age; no GRADE assessment was reported.

2 findings from 1 review

Graphs of study contributions and covariate distributions for network meta-regression. 2018 All outcomes
Average age (years), NMR covariate
no estimate extracted
Studies not reported
GRADE not reported
Graphs of study contributions and covariate distributions for network meta-regression. 2018 All outcomes
Network meta-regression covariate: average age (years)
no estimate extracted
Studies not reported
GRADE not reported

Artesunate vs Artemether

Death · Patients with severe malaria

In the illustrative network meta-regression no difference in the log odds ratio for death between artesunate and artemether was seen at any displayed average age; certainty was not graded.

1 finding from 1 review

Graphs of study contributions and covariate distributions for network meta-regression. 2018 All outcomes
Network meta-regression covariate: average age (years)
no estimate extracted
Studies not reported
GRADE not reported

Intervention not reported

Death · Children with severe malaria

The intervention leads to lower death (high certainty).

1 finding from 1 review

Artesunate versus quinine for treating severe malaria 2012 · Cochrane Headline outcomes only
RR 0.76 [0.65, 0.9]
4 studies · 5765 participants
High

Intervention not reported

Death · Adults with severe malaria

The intervention leads to lower death (high certainty).

1 finding from 1 review

Artesunate versus quinine for treating severe malaria 2012 · Cochrane Headline outcomes only
RR 0.61 [0.5, 0.75]
5 studies · 1664 participants
High