Findings

What do systematic reviews say?

5 questions · 6 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 3 · 50%Very low 0 · 0%Low 0 · 0%Moderate 3 · 50%High 0 · 0%

Artemether vs Quinine

Death · Patients with severe malaria

The fixed-effect NMR reported a difference between artemether and quinine at ages 15 years or more; no GRADE assessment was reported.

2 findings from 1 review

Graphs of study contributions and covariate distributions for network meta-regression. 2018 All outcomes
Average age (years), NMR covariate
no estimate extracted
Studies not reported
GRADE not reported
Graphs of study contributions and covariate distributions for network meta-regression. 2018 All outcomes
Network meta-regression covariate: average age (years)
no estimate extracted
Studies not reported
GRADE not reported

Artesunate vs Artemether

Death · Patients with severe malaria

In the illustrative network meta-regression no difference in the log odds ratio for death between artesunate and artemether was seen at any displayed average age; certainty was not graded.

1 finding from 1 review

Graphs of study contributions and covariate distributions for network meta-regression. 2018 All outcomes
Network meta-regression covariate: average age (years)
no estimate extracted
Studies not reported
GRADE not reported

Intervention not reported

Death · children with severe malaria

The intervention showed no clear difference in death (moderate certainty).

1 finding from 1 review

Artemether for severe malaria 2019 · Cochrane Headline outcomes only
RR 0.97 [0.77, 1.21]
13 studies · 1659 participants
Moderate

Intervention not reported

Death · adults with severe malaria

The intervention probably leads to higher death (moderate certainty).

1 finding from 1 review

Artemether for severe malaria 2019 · Cochrane Headline outcomes only
RR 1.8 [1.09, 2.97]
2 studies · 494 participants
Moderate

Intervention not reported

Death · adults with severe malaria

The intervention probably leads to lower death (moderate certainty).

1 finding from 1 review

Artemether for severe malaria 2019 · Cochrane Headline outcomes only
RR 0.59 [0.42, 0.83]
4 studies · 716 participants
Moderate