Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

10 questions · 10 findings · 3 reviews

No studies found 5 · 50%GRADE not reported 0 · 0%Very low 1 · 10%Low 2 · 20%Moderate 2 · 20%High 0 · 0%

Aldosterone antagonists vs placebo or usual care

All cardiovascular death · people with chronic kidney disease requiring dialysis

Aldosterone antagonists (spironolactone or eplerenone) probably leads to lower death (cardiovascular) compared with control (placebo or standard care) (moderate certainty).

1 finding from 1 review

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

Death · proteinuric chronic kidney disease

Non‐steroidal mineralocorticoid receptor antagonist showed no clear difference in death compared with selective aldosterone antagonist (low certainty).

1 finding from 1 review