What do systematic reviews say?

5 questions · 5 findings · 3 reviews · Periodontology

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No studies found 1 · 20%GRADE not reported 4 · 80%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs usual care or no treatment

Diabetic complications · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age

The review found no eligible studies for this question.

1 finding from 1 review

Treatment of periodontitis for glycaemic control in people with diabetes mellitus 2022 · Cochrane All outcomes
3-4 months
Included studies did not report data on diabetic complications (some reported medication changes only)
0 studies
No studies found

Enamel matrix derivative (EMD; Emdogain) vs Guided tissue regeneration (GTR) with barriers

Postoperative complications (infection) / adverse events · Patients affected by chronic, aggressive, or early onset periodontitis, with intrabony defects having an intrabony component of at least 3…

Enamel matrix derivative (EMD; Emdogain) led to lower postoperative complications (infection) / adverse events compared with guided tissue regeneration (GTR) with barriers; GRADE not reported.

1 finding from 1 review

Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes
1 year (time-points 1, 5 and 10 years planned)
RR 0.12 [0.02, 0.85]
3 studies
GRADE not reported

Enamel matrix derivative (EMD; Emdogain) vs Various bone grafting (BG) procedures (animal-derived or synthetic bone / bioactive ceramic filler)

1 finding from 1 review

Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes
1 year (time-points 1, 5 and 10 years planned)
Complications and other adverse events: none occurred.
1 study
GRADE not reported

Enamel matrix derivative (EMD; Emdogain) vs placebo or control

1 finding from 1 review

Enamel matrix derivative (Emdogain®) for periodontal tissue regeneration in intrabony defects 2009 · Cochrane All outcomes
1 year (time-points 1, 5 and 10 years planned)
No particular adverse events or infection attributable to EMD in any trial; no differences in pain, edema, hematoma, wound dehiscence or root sensitivity (Tonetti 2002).
9 studies
GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Post-operative adverse events and complications · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

1 finding from 1 review

Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
Adverse effects were generally minor. Healing was generally uneventful for both test and control groups. Exposure of the GTR barrier membrane was widely reported, ranging from 20% of sites (non-resorbable…
16 studies
GRADE not reported