Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 1 · 50%High 0 · 0%

Completion of treatment · People undergoing managed opioid withdrawal

Alpha2‐adrenergic agonist showed no clear difference in completion of treatment compared with methadone (low certainty).

1 finding from 1 review

Alpha₂‐adrenergic agonists for the management of opioid withdrawal 2016 · Cochrane Headline outcomes only
RR 0.85 [0.69, 1.05]
9 studies · 659 participants
Low

Completion of treatment · People undergoing managed opioid withdrawal

Alpha2‐adrenergic agonist probably leads to higher completion of treatment compared with placebo (moderate certainty).

1 finding from 1 review

Alpha₂‐adrenergic agonists for the management of opioid withdrawal 2016 · Cochrane Headline outcomes only
RR 1.95 [1.34, 2.84]
3 studies · 148 participants
Moderate