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Evidence found and GRADE certainty

6 questions · 6 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 33.3%Moderate 4 · 66.7%High 0 · 0%

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

Complete remission · primary membranous nephropathy in adults with nephrotic syndrome

Immunosuppressive treatment probably leads to higher complete remission at final compared with placebo/no treatment/non‐immunosuppressive supportive treatment (moderate certainty).

1 finding from 1 review

Immunosuppressive treatment vs placebo/no treatment/non‐immunosuppressive supportive treatment

Total remission (complete or partial) at final · primary membranous nephropathy in adults with nephrotic syndrome

Immunosuppressive treatment probably leads to higher total remission (complete or partial) at final compared with placebo/no treatment/non‐immunosuppressive supportive treatment (moderate certainty).

1 finding from 1 review

Oral alkylating agents ± steroids vs steroids or placebo or both, or no treatment

Complete remission · primary membranous nephropathy in adults with nephrotic syndrome

Oral alkylating agents ± steroids probably leads to higher complete remission at final compared with placebo/no treatment/steroids (moderate certainty).

1 finding from 1 review

Calcineurin inhibitors ± steroids vs placebo/no treatment/supportive treatment/steroids

Complete remission · primary membranous nephropathy in adults with nephrotic syndrome

Calcineurin inhibitors ± steroids showed no clear difference in complete remission at final compared with placebo/no treatment/supportive treatment/steroids (low certainty).

1 finding from 1 review

Oral alkylating agents ± steroids vs steroids or placebo or both, or no treatment

Total remission (complete or partial) at final · primary membranous nephropathy in adults with nephrotic syndrome

Oral alkylating agents ± steroids probably leads to higher total remission (complete or partial) at final compared with placebo/no treatment/steroids (moderate certainty).

1 finding from 1 review

Calcineurin inhibitors ± steroids vs alkylating agents ± steroids

Complete remission · primary membranous nephropathy in adults with nephrotic syndrome

Calcineurin inhibitors ± steroids showed no clear difference in complete remission at final compared with alkylating agents ± steroids (low certainty).

1 finding from 1 review