Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Kidney and Transplant

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 0 · 0%Moderate 2 · 66.7%High 0 · 0%

Intravenous ± oral steroids vs oral steroids alone

Complete remission · minimal change disease in adults with nephrotic syndrome

It is very uncertain whether intravenous ± oral steroids changes complete remission Time frame: 2 to 28 months compared with oral steroids alone (very low certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 1.76 [0.17, 18.32]
2 studies · 35 participants
Very low

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Complete remission · minimal change disease in adults with nephrotic syndrome

Calcineurin inhibitors ± oral steroids showed no clear difference in complete remission Time frame: 2 to 6 months compared with oral steroids alone (moderate certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 0.99 [0.93, 1.05]
8 studies · 492 participants
Moderate

Calcineurin inhibitors ± oral steroids vs oral steroids alone

Complete or partial remission · minimal change disease in adults with nephrotic syndrome

Calcineurin inhibitors ± oral steroids showed no clear difference in complete or partial remission time frame: 3 to 6 months compared with oral steroids alone (moderate certainty).

1 finding from 1 review

Interventions for minimal change disease in adults with nephrotic syndrome 2022 · Cochrane Headline outcomes only
RR 1.01 [0.96, 1.05]
4 studies · 269 participants
Moderate