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What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 8 findings · 2 reviews · Vascular

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No studies found 4 · 50%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 12.5%Moderate 2 · 25%High 1 · 12.5%

Heparin vs placebo

Clinically relevant non‐major bleeding Treatment duration 28 ‐ 42 days · people requiring prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair

The review found no eligible studies for this question.

1 finding from 1 review

Low molecular weight heparin vs active control

Clinically relevant bleeding · ambulatory cancer patients receiving chemotherapy

The review found no eligible studies for this question.

3 findings from 1 review

DOAC vs heparin

Clinically relevant non‐major bleeding Treatment duration 28 ‐ 42 days · people requiring prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair

DOAC showed no clear difference in bleeding ‐ clinically relevant, non‐major Treatment duration 28 ‐ 42… compared with heparin (high certainty).

1 finding from 1 review