Interventions probably leads to lower clinically important upper GI bleeding compared with placebo or no prophylaxis (moderate certainty).
Proton pump inhibitors showed no clear difference in clinically important upper GI bleeding compared with placebo or no prophylaxis (low certainty).
Antacids may leads to lower clinically important upper GI bleeding compared with placebo or no prophylaxis (low certainty).
Sucralfate probably leads to lower clinically important upper GI bleeding compared with placebo or no prophylaxis (moderate certainty).
H2 receptor antagonists may leads to higher clinically important upper GI bleeding compared with proton pump inhibitors (low certainty).
H2 receptor antagonists showed no clear difference in clinically important upper GI bleeding compared with antacids (low certainty).
H2 receptor antagonists showed no clear difference in clinically important upper GI bleeding compared with sucralfate (low certainty).
Antacids showed no clear difference in clinically important upper GI bleeding compared with sucralfate (low certainty).
H2 receptor antagonists probably leads to lower clinically important upper GI bleeding compared with placebo or no prophylaxis (moderate certainty).