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What do systematic reviews say?

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Evidence found and GRADE certainty

3 questions · 3 findings · 1 reviews

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No studies found 1 · 33.3%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 0 · 0%Moderate 0 · 0%High 1 · 33.3%

Summary of findings table ‐ Convalescent plasma vs standard plasma

Clinical worsening: need for invasive mechanical ventilation, or death at up to day 28 · individuals with moderate to severe disease

It is very uncertain whether summary of findings table ‐ Convalescent plasma changes clinical worsening: need for invasive mechanical ventilation, or… compared with standard plasma (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Convalescent plasma vs placebo or usual care

Clinical worsening: need for invasive mechanical ventilation, or death at up to day 28 · individuals with moderate to severe disease

Summary of findings table ‐ Convalescent plasma showed no clear difference in clinical worsening: need for invasive mechanical ventilation, or… compared with placebo or standard care alone (high certainty).

1 finding from 1 review