Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

7 questions · 7 findings · 5 reviews · Haematology

No studies found 1 · 14.3%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 0 · 0%Moderate 3 · 42.9%High 1 · 14.3%

Summary of findings table ‐ Convalescent plasma vs placebo or usual care

Clinical worsening: need for invasive mechanical ventilation, or death at up to day 28 · individuals with moderate to severe disease

Summary of findings table ‐ Convalescent plasma showed no clear difference in clinical worsening: need for invasive mechanical ventilation, or… compared with placebo or standard care alone (high certainty).

1 finding from 1 review

Summary of findings table ‐ Convalescent plasma vs standard plasma

Clinical worsening: need for invasive mechanical ventilation, or death at up to day 28 · individuals with moderate to severe disease

It is very uncertain whether summary of findings table ‐ Convalescent plasma changes clinical worsening: need for invasive mechanical ventilation, or… compared with standard plasma (very low certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

Clinical worsening: new need for invasive mechanical ventilation or death · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care probably leads to lower clinical worsening: time to new need for invasive mechanical… compared with standard care (plus/minus placebo) (moderate certainty).

1 finding from 1 review

Intervention not reported

Worsening of clinical status: participants with new need for invasive mechanical ventilation or death at day 28 · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

It is very uncertain whether the intervention changes worsening of clinical status: participants with new need for… (very low certainty).

1 finding from 1 review

Azithromycin vs placebo or usual care

Clinical worsening: need for invasive mechanical ventilation, or death at up to day 28 · people with moderate to severe disease (WHO scale 4–9); all studies contributing results to the summary of findings table included people…

Azithromycin showed no clear difference in worsening of clinical status: participants with clinical… compared with placebo or standard of care alone (moderate certainty).

1 finding from 1 review