Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews · Cystic Fibrosis and Genetic Disorders

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Stroke · prevention of SCI in people with SCD who have not had a stroke (primary prevention)

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 121 participants
Very low

Stroke · prevention of SCI in people with SCD who had a stroke (secondary prevention)

It is very uncertain whether hydroxyurea changes clinical stroke compared with RBC transfusion (very low certainty).

1 finding from 1 review

Interventions for preventing silent cerebral infarcts in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 14.78 [0.86, 253.66]
1 study · 133 participants
Very low

Stroke · individuals with sickle cell disease who are at risk of a primary stroke who have had long‐term red cell transfusions to prevent a stroke

1 finding from 1 review

Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 121 participants
Very low

Stroke · individuals with sickle cell disease who have had a stroke who have had long‐term red cell transfusions to prevent another stroke

It is very uncertain whether long‐term red cell transfusion changes clinical stroke compared with hydroxyurea and phlebotomy (very low certainty).

1 finding from 1 review

Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease 2020 · Cochrane Headline outcomes only
RR 14.78 [0.86, 253.66]
1 study · 133 participants
Very low