Findings

What do systematic reviews say?

7 questions · 7 findings · 2 reviews · Oral medicine and oral cancer

No studies found 0 · 0%GRADE not reported 2 · 28.6%Very low 3 · 42.9%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Intralesional betamethasone may leads to higher clinical resolution compared with intralesional triamcinolone acetonide (low certainty).

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
RR 1.40 [1.06, 1.83]
1 study · 59 participants
Low

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
Amirchaghmaghi 2016: no difference in clinical resolution with vs without curcumin (very low-certainty)
1 study
Very low

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
Wei 2003: no difference in clinical resolution between dexamethasone with vs without nystatin (very low-certainty)
1 study
Very low

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical triamcinolone acetonide changes clinical resolution compared with topical tacrolimus (very low certainty).

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
3-8 weeks
RR 0.86 [0.55, 1.35]
2 studies · 60 participants
Very low

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
Bakhtiari 2017 (dexamethasone mouthwash + nystatin vs photodynamic therapy): clinical resolution reported (Analysis 4.6); no clear difference (low to very low certainty collectively)
1 study
GRADE not reported

Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia

1 finding from 1 review

Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes
3 to 6 months
SoF 4, Clinical resolution (not completely resolved) at 3 to 6 months: '3 studies (freeze-dried black raspberry gel, green tea extract capsules, mixed tea) did not find evidence of benefit.' No GRADE. Effects text:…
4 studies
GRADE not reported

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Clobetasol propionate ointment may leads to higher clinical resolution compared with triamcinolone acetonide ointment (low certainty).

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
RR 1.56 [1.09, 2.21]
2 studies · 57 participants
Low