Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 2 · 66.7%Moderate 0 · 0%High 0 · 0%

Clinical remission · adults with refractory, moderate‐to‐severe ulcerative colitis

Tacrolimus may leads to higher clinical remission compared with placebo (low certainty).

1 finding from 1 review

Tacrolimus (FK506) for induction of remission in corticosteroid‐refractory ulcerative colitis 2022 · Cochrane Headline outcomes only
RR 3.76 [1.03, 13.73]
3 studies · 148 participants
Low

Clinical remission · adults with refractory, moderate‐to‐severe ulcerative colitis

It is very uncertain whether tacrolimus changes clinical remission compared with ciclosporin (very low certainty).

1 finding from 1 review

Tacrolimus (FK506) for induction of remission in corticosteroid‐refractory ulcerative colitis 2022 · Cochrane Headline outcomes only
RR 1.52 [0.92, 2.5]
1 study · 113 participants
Very low

Clinical remission · adults with refractory, moderate‐to‐severe ulcerative colitis

Tacrolimus showed no clear difference in clinical remission compared with beclometasone (low certainty).

1 finding from 1 review