Findings

What do systematic reviews say?

6 questions · 9 findings · 4 reviews · Gynaecology and Fertility

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 22.2%Low 3 · 33.3%Moderate 4 · 44.4%High 0 · 0%

Metformin combined with clomiphene citrate vs clomiphene

Clinical pregnancy rate · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate probably leads to higher clinical pregnancy rate per woman compared with clomiphene citrate alone (moderate certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.62 [1.32, 1.99]
19 studies · 1790 participants
Moderate
Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.59 [1.27, 1.99]
16 studies · 1529 participants
Moderate

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · for controlled ovarian stimulation

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonists or midcycle antagonist) (moderate certainty).

1 finding from 1 review

Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian… 2017 · Cochrane Headline outcomes only
RR 1 [0.86, 1.16]
12 studies · 1998 participants
Moderate

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · Women undergoing controlled ovarian stimulation in IVF and ICSI cycles (poor responders)

1 finding from 1 review

Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian… 2017 · Cochrane Headline outcomes only
RR 0.85 [0.64, 1.12]
8 studies · 1462 participants
Low

Gonadotrophins vs continued clomiphene citrate

Clinical pregnancy rate · anovulatory women with clomiphene citrate‐failure

Gonadotrophins probably leads to higher clinical pregnancy rate per woman compared with continued clomiphene citrate (moderate certainty).

1 finding from 1 review

Gonadotrophins for ovulation induction in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
RR 1.31 [1.13, 1.52]
1 study · 661 participants
Moderate

Metformin vs clomiphene

Clinical pregnancy rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome

Metformin may leads to lower clinical pregnancy rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 0.34 [0.21, 0.55]
2 studies · 500 participants
Low
Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 0.34 [0.21, 0.55]
2 studies · 500 participants
Very low

Metformin vs clomiphene

Clinical pregnancy rate per woman Participants with BMI < 30 kg/m2 or ≤ 32 kg/m2a · women with polycystic ovary syndrome

Metformin may leads to higher clinical pregnancy rate per womanaParticipants with BMI < 30 kg/m2… compared with clomiphene citrate (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.56 [1.06, 2.29]
6 studies · 530 participants
Low
Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.56 [1.05, 2.33]
5 studies · 490 participants
Very low