Findings

What do systematic reviews say?

20 questions · 21 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 5 · 23.8%Very low 9 · 42.9%Low 7 · 33.3%Moderate 0 · 0%High 0 · 0%

Ferric sulphate (FS) vs Ankaferd Blood Stopper (ABS)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether ferric sulphate (FS) changes clinical failure compared with ankaferd Blood Stopper (ABS) (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 1.25 [0.37, 4.27]
2 studies · 100 participants
Very low

Ferric sulphate (FS) vs Formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Ferric sulphate (FS) showed no clear difference in clinical failure compared with formocresol (FC) (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 1.38 [0.45, 4.27]
6 studies · 394 participants
Low

Ferric sulphate (FS) vs Zinc oxide and eugenol (ZOE)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Ferric sulphate (FS) showed no clear difference in clinical failure compared with zinc oxide and eugenol (ZOE); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 1.20 [0.42, 3.43]
1 study · 50 participants
GRADE not reported

Ferric sulphate (FS) + mineral trioxide aggregate (MTA) vs Zinc oxide and eugenol (ZOE) pulpectomy

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Ferric sulphate/MTA pulpotomy showed no clear difference in clinical failure compared with zinc oxide and eugenol (ZOE) pulpectomy; GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
18 months
RR 2.16 [0.23, 20.35]
1 study · 172 participants
GRADE not reported

Calcium-enriched mixture (CEM) cement vs Mineral trioxide aggregate (MTA)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

2 findings from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6, 12 and 18 months
No clinical failure in any participant (Malekafzali 2011); not estimable
1 study · 80 participants
GRADE not reported
Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 3.00 [0.13, 69.70]
1 study · 42 participants
Very low

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Calcium hydroxide (CH)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes clinical failure compared with calcium hydroxide (CH) (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 and 24 months
RR 3.00 [0.13, 69.52]
1 study · 40 participants
Very low

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Non-rinse conditioner + acetone-based total-etch adhesive

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes clinical failure compared with non-rinse conditioner + acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 and 24 months
RR 3.00 [0.13, 69.52]
1 study · 40 participants
Very low

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Acetone-based total-etch adhesive

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes clinical failure compared with acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 and 24 months
RR 3.00 [0.13, 69.52]
1 study · 40 participants
Very low

Benznidazole vs placebo

Clinical improvement (N) (a) Heart failure (b) Sustained ventricular tachycardia · adults with both late‐stage, symptomatic Chagas disease and CCC

Benznidazole showed no clear difference in clinical improvement (N) (a) Heart failure (b) Sustained ventricular… compared with placebo (low certainty).

1 finding from 1 review

Trypanocidal drugs for late‐stage, symptomatic Chagas disease (Trypanosoma cruzi infection) 2020 · Cochrane Headline outcomes only
RR 0.89 [0.69, 1.14]
1 study · 2854 participants
Low

Cefixime vs fluoroquinolones

Clinical failure · adults and children with enteric fever

Cefixime may leads to higher clinical failure compared with fluoroquinolones (low certainty).

1 finding from 1 review

Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins 2022 · Cochrane Headline outcomes only
RR 13.39 [3.24, 55.39]
2 studies · 240 participants
Low

Ceftriaxone vs fluoroquinolones

Clinical failure · adults and children with enteric fever

It is very uncertain whether ceftriaxone changes clinical failure compared with fluoroquinolones (very low certainty).

1 finding from 1 review

Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins 2022 · Cochrane Headline outcomes only
RR 3.77 [0.72, 19.81]
4 studies · 359 participants
Very low

Ceftriaxone vs azithromycin

Clinical failure · children under 18 years of age with enteric fever

Ceftriaxone showed no clear difference in clinical failure compared with azithromycin (low certainty).

1 finding from 1 review

Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins 2022 · Cochrane Headline outcomes only
RR 0.42 [0.11, 1.57]
3 studies · 196 participants
Low

Electrosurgery vs Ferric sulphate (FS)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Electrosurgery showed no clear difference in clinical failure compared with ferric sulphate (FS) (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 0.56 [0.13, 2.34]
2 studies · 50 participants
Low

Diode laser vs Ferric sulphate (FS)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Diode laser showed no clear difference in clinical failure compared with ferric sulphate (FS) (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 0.23 [0.04, 1.30]
3 studies · 130 participants
Low

Calcium hydroxide (CH) vs Ferric sulphate (FS)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Calcium hydroxide (CH) showed no clear difference in clinical failure compared with ferric sulphate (FS) (low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 3.41 [0.37, 31.61]
2 studies · 122 participants
Low

Self-etch adhesive + acetone-based total-etch adhesive vs Total-etching 36% phosphoric acid + acetone-based total-etch adhesive

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes clinical failure compared with total-etching 36% phosphoric acid + acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 and 24 months
RR 1.00 [0.07, 14.90]
1 study · 40 participants
Very low

Erbium:YAG laser vs Ferric sulphate (FS)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Erbium:YAG laser showed no clear difference in clinical failure compared with ferric sulphate (FS); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 5.31 [0.26, 107.86]
1 study · 97 participants
GRADE not reported

Electrosurgery vs Calcium-enriched mixture (CEM)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6, 12 and 24 months
No clinical failure in any participant at 6/12/24 months (Khorakian 2014); not estimable
1 study · 102 participants
GRADE not reported

Sodium hypochlorite (NaOCl) vs Ferric sulphate (FS)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether sodium hypochlorite (NaOCl) changes clinical failure compared with ferric sulphate (FS) (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 4.39 [0.22, 87.82]
2 studies · 110 participants
Very low

Mineral trioxide aggregate (MTA) vs Ferric sulphate (FS)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether mineral trioxide aggregate (MTA) changes clinical failure compared with ferric sulphate (FS) (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 0.52 [0.20, 1.39]
3 studies · 130 participants
Very low