Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 1 · 25%Moderate 2 · 50%High 0 · 0%

Ceftriaxone vs fluoroquinolones

Clinical failure · adults and children with enteric fever

It is very uncertain whether ceftriaxone changes clinical failure compared with fluoroquinolones (very low certainty).

1 finding from 1 review

Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins 2022 · Cochrane Headline outcomes only
RR 3.77 [0.72, 19.81]
4 studies · 359 participants
Very low

Ceftriaxone vs azithromycin

Clinical failure · children under 18 years of age with enteric fever

Ceftriaxone showed no clear difference in clinical failure compared with azithromycin (low certainty).

1 finding from 1 review

Treatment of enteric fever (typhoid and paratyphoid fever) with cephalosporins 2022 · Cochrane Headline outcomes only
RR 0.42 [0.11, 1.57]
3 studies · 196 participants
Low

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Clinical failure ‐ in all participants ‐ short term Composite clinical criteria10 · people suspected to have meningococcal disease (adults and children)

Ceftriaxone showed no clear difference in clinical failure ‐ in all participants ‐ short term Composite… compared with long‐acting (oily) chloramphenicol (moderate certainty).

1 finding from 1 review

Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
OR 0.83 [0.32, 2.15]
1 study · 477 participants
Moderate

Ceftriaxone vs long‐acting (oily) Chloramphenicol compared

Clinical failure ‐ in confirmed cases of meningococcal meningitis (subgroup) Composite clinical criteria10 · people suspected to have meningococcal disease (adults and children)

Ceftriaxone showed no clear difference in clinical failure ‐ in confirmed cases of meningococcal meningitis… compared with long‐acting (oily) chloramphenicol (moderate certainty).

1 finding from 1 review

Pre‐admission antibiotics for suspected cases of meningococcal disease 2017 · Cochrane Headline outcomes only
OR 1.39 [0.23, 8.47]
1 study · 308 participants
Moderate