Clinical attachment level (CAL) · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)
Mechanical debridement plus local antimicrobial (minocycline… showed no clear difference in clinical attachment level (mm) compared with mechanical debridement alone (low certainty).
1 finding from 1 review
Clinical attachment level (CAL) · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)
It is very uncertain whether photodynamic therapy plus mechanical debridement changes clinical attachment level (mm) compared with mechanical debridement alone (very low certainty).
1 finding from 1 review
Clinical attachment level (CAL) · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination
Periodontal treatment (scaling and root planing, alone or with… led to lower clinical attachment level compared with alternative (less intensive) periodontal treatment, alone or with…; GRADE not reported.
1 finding from 1 review
Clinical attachment level (CAL) · People with diabetes mellitus (type 1 or type 2, mostly type 2) and periodontitis, at least 16 years of age
Periodontal treatment (subgingival instrumentation, with or without… led to lower clinical attachment level (CAL) compared with no active intervention/usual care; GRADE not reported.
1 finding from 1 review
MD -0.48 [-0.65, -0.31]
18 studies
GRADE not reported
Clinical attachment level (CAL) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
Periodontal treatment (subgingival SRP with or without other… led to lower clinical attachment level (CAL) compared with no treatment (no periodontal treatment); GRADE not reported.
1 finding from 1 review
Clinical attachment level (CAL) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension
Intensive periodontal treatment (subgingival SRP with or without… led to lower clinical attachment level (CAL) compared with supra-gingival scaling; GRADE not reported.
3 findings from 1 review
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with metronidazole + SRP; GRADE not reported.
3 findings from 1 review
MD 0.34 [-0.08, 0.76]
3 studies · 75 participants
GRADE not reported
MD 1.10 [0.36, 1.84]
1 study · 27 participants
Very low
MD -0.12 [-0.72, 0.49]
2 studies · 49 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
It is very uncertain whether doxycycline + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
3 findings from 1 review
MD -0.80 [-1.49, -0.11]
1 study · 22 participants
Very low
MD -0.61 [-1.14, -0.08]
3 studies · 65 participants
GRADE not reported
MD 0.15 [-0.53, 0.83]
2 studies · 43 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with clarithromycin + SRP; GRADE not reported.
2 findings from 1 review
Clinical attachment level (CAL) · Adults with aggressive periodontitis
It is very uncertain whether clindamycin + SRP changes clinical attachment level (CAL) compared with doxycycline + SRP (very low certainty).
3 findings from 1 review
MD -0.90 [-1.62, -0.18]
1 study · 23 participants
Very low
MD -0.40 [-1.15, 0.35]
1 study · 23 participants
GRADE not reported
MD 0.50 [-0.26, 1.26]
1 study · 23 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Tetracycline + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.
3 findings from 1 review
MD -1.90 [-2.17, -1.63]
1 study · 26 participants
GRADE not reported
MD -2.30 [-2.50, -2.10]
1 study · 26 participants
Very low
MD -0.92 [-2.38, 0.54]
2 studies · 64 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Clindamycin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.
3 findings from 1 review
MD -1.30 [-2.14, -0.46]
1 study · 21 participants
GRADE not reported
MD 0.40 [-0.35, 1.15]
1 study · 21 participants
GRADE not reported
MD -1.70 [-2.40, -1.00]
1 study · 21 participants
Very low
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Doxycycline + SRP showed no clear difference in clinical attachment level (CAL) compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
Clarithromycin + SRP led to lower clinical attachment level (CAL) compared with SRP; GRADE not reported.
2 findings from 1 review
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
Metronidazole + SRP showed no clear difference in clinical attachment level (CAL) compared with amoxicillin + metronidazole + SRP; GRADE not reported.
2 findings from 1 review
Clinical attachment level (CAL) · Adults with chronic periodontitis
Cefixime + SRP showed no clear difference in clinical attachment level (CAL) compared with SRP; GRADE not reported.
1 finding from 1 review
Clinical attachment level (CAL) · Adults with chronic periodontitis
Amoxicillin + clavulanate + SRP showed no clear difference in clinical attachment level (CAL) compared with SRP; GRADE not reported.
3 findings from 1 review
MD 0.10 [-0.45, 0.65]
1 study · 21 participants
GRADE not reported
MD 0.10 [-0.51, 0.71]
1 study · 21 participants
Very low
MD 0.10 [-0.43, 0.63]
1 study · 21 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with aggressive periodontitis
Clindamycin + SRP showed no clear difference in clinical attachment level (CAL) compared with metronidazole + SRP; GRADE not reported.
3 findings from 1 review
MD 0.40 [-0.22, 1.02]
1 study · 26 participants
GRADE not reported
MD 0.20 [-0.55, 0.95]
1 study · 26 participants
Very low
MD 0.10 [-0.60, 0.80]
1 study · 26 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether amoxicillin + metronidazole + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
3 findings from 1 review
MD -0.47 [-0.90, -0.05]
2 studies · 389 participants
Very low
MD -0.21 [-0.41, -0.01]
13 studies · 501 participants
GRADE not reported
MD -0.04 [-0.35, 0.26]
6 studies · 215 participants
GRADE not reported
Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether azithromycin + SRP changes clinical attachment level (CAL) compared with SRP (very low certainty).
3 findings from 1 review
MD -0.59 [-1.27, 0.08]
2 studies · 110 participants
Very low
MD -0.43 [-0.77, -0.10]
7 studies · 258 participants
GRADE not reported
MD -0.51 [-0.83, -0.19]
6 studies · 216 participants
GRADE not reported