What do systematic reviews say?

Very early treatment vs expectant management

Very early treatment showed no clear difference in chronic lung disease compared with expectant management (low certainty).

• Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants 2020 · Cochrane Headline outcomes only
  RR 0.83 [0.63, 1.08]
  7 studies · 384 participants
  Low