Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 3 · 100%High 0 · 0%

Intrathecal injected nusinersen vs sham

Change in disability score · children with SMA type II

Intrathecal injected nusinersen probably leads to higher change in disability score compared with sham procedure (moderate certainty).

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
MD 5.9 [3.7, 8.1]
1 study · 126 participants
Moderate

Intrathecal injected nusinersen vs sham

Change in disability score (3 point‐change) · children with SMA type II

Intrathecal injected nusinersen showed no clear difference in change in disability score (3 point‐change) compared with sham procedure (moderate certainty).

1 finding from 1 review

Drug treatment for spinal muscular atrophy types II and III 2020 · Cochrane Headline outcomes only
RR 1.8 [0.99, 3.1]
1 study · 126 participants
Moderate

Intrathecal injected nusinersen vs sham

Change in motor score after one year · infants with SMA and 2 SMN2 copies

Intrathecal injected nusinersen probably leads to higher change in motor disability score ‐ response on HINE‐2 within one… compared with sham procedure (moderate certainty).

1 finding from 1 review

Drug treatment for spinal muscular atrophy type I 2019 · Cochrane Headline outcomes only
RR 38.51 [2.43, 610.14]
1 study · 110 participants
Moderate