Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Dental caries

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No studies found 0 · 0%GRADE not reported 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Consumption of xylitol chewing gum by women (mothers) vs no intervention

Change in Mutans streptococci (MS) count in saliva · healthy people

Xylitol significantly reduced Mutans streptococci in saliva compared with no intervention (SMD -1.47, 95% CI -1.94 to -0.99; 3 trials), though heterogeneity was very high (I2=98%); not GRADE-rated.

1 finding from 1 review

Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis. 2024 All outcomes
Post-consumption endpoint (varied durations across trials) · All age groups, generally healthy; multiple countries; sugar substitutes delivered as chewing gum, milk, candy, or tablets · Xylitol chewing gum vs no intervention/no gum (3 studies)
SMD -1.47 [-1.94, -0.99]
3 studies · 136 participants
GRADE not reported

Xylitol (low-intensity sweetener/sugar alcohol) in food products (chewing gum, milk, candy, or tablets) vs Sorbitol (low-intensity sweetener)

Change in Mutans streptococci (MS) count in saliva · healthy people

Xylitol and sorbitol did not differ significantly for Mutans streptococci in saliva (SMD -0.16, 95% CI -0.44 to 0.12; 2 trials, P=.25); not GRADE-rated.

1 finding from 1 review

Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis. 2024 All outcomes
Post-consumption endpoint (varied durations across trials) · All age groups, generally healthy; multiple countries; sugar substitutes delivered as chewing gum, milk, candy, or tablets · Xylitol gum vs sorbitol gum (2 studies)
SMD -0.16 [-0.44, 0.12]
2 studies · 201 participants
GRADE not reported