What do systematic reviews say?

Fluoride varnish vs Fluoride in rinse

The illustrative network meta-regression estimated an SMD for caries increment for fluoride in varnish versus fluoride in rinse across randomization year; the review did not state whether the difference was significant and certainty was not graded.

• Graphs of study contributions and covariate distributions for network meta-regression. 2018 All outcomes

  At least 1 year or school year · Network meta-regression covariate: randomization year
  no estimate extracted
  Studies not reported
  GRADE not reported

Fluoride gel combined with fluoride toothpaste vs Fluoride gel

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes

  Nearest to 3 years
  PF 0.10 [-0.01, 0.21]
  3 studies · 759 participants
  GRADE not reported

Fluoride gel combined with fluoride toothpaste vs Fluoride toothpaste alone

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes

  Nearest to 3 years
  PF 0.14 [-0.09, 0.38]
  3 studies · 1217 participants
  GRADE not reported

Fluoride varnish combined with fluoride toothpaste vs Fluoride toothpaste alone

• Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes

  Nearest to 3 years
  PF 0.48 [0.12, 0.84]
  1 study · 71 participants
  GRADE not reported