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Evidence found and GRADE certainty

5 questions · 5 findings · 1 reviews · Heart

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 20%Moderate 3 · 60%High 1 · 20%

Angiotensin‐converting enzyme inhibitors vs placebo or no treatment

Cardiovascular mortality · patients with chronic heart failure with preserved ejection fraction

Angiotensin‐converting enzyme inhibitors (ACEIs) showed no clear difference in cardiovascular mortality (RR) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Angiotensin receptor neprilysin inhibitors (ARNIs) vs usual care

Cardiovascular mortality · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor neprilysin inhibitors (ARNIs) showed no clear difference in cardiovascular mortality (RR) Median compared with usual care (moderate certainty).

1 finding from 1 review

Angiotensin receptor blockers (ARBs) vs placebo or no treatment

Cardiovascular mortality · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor blockers (ARBs) showed no clear difference in cardiovascular mortality (RR) compared with placebo or no treatment (high certainty).

1 finding from 1 review

Mineralocorticoid receptor antagonists (MRAs) vs placebo or no treatment

Cardiovascular mortality · patients with chronic heart failure with preserved ejection fraction

Mineralocorticoid receptor antagonists (MRAs) showed no clear difference in cardiovascular mortality (RR) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review