What do systematic reviews say?

Metformin vs diet and exercise or another antidiabetic drug

The review found no eligible studies for this question.

• Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: pioglitazone monotherapy vs another pharmacological glucose‐lowering monotherapy

The review found no eligible studies for this question.

• Pioglitazone for prevention or delay of type 2 diabetes mellitus and its associated complications in people at risk… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: pioglitazone monotherapy vs intensive behaviour‐changing intervention

The review found no eligible studies for this question.

• Pioglitazone for prevention or delay of type 2 diabetes mellitus and its associated complications in people at risk… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: pioglitazone monotherapy vs placebo

It is very uncertain whether summary of findings: pioglitazone monotherapy changes cardiovascular mortality (N) compared with placebo (very low certainty).

• Pioglitazone for prevention or delay of type 2 diabetes mellitus and its associated complications in people at risk… 2020 · Cochrane Headline outcomes only
  RR 5.14 [0.25, 106.28]
  4 studies · 1156 participants
  Very low

Summary of findings: pioglitazone monotherapy vs no intervention

The review found no eligible studies for this question.

• Pioglitazone for prevention or delay of type 2 diabetes mellitus and its associated complications in people at risk… 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings table for metformin plus intensive diet and exercise vs intensive diet and exercise

The review found no eligible studies for this question.

• Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs meglitinides

The review found no eligible studies for this question.

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs insulin

The review found no eligible studies for this question.

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin vs sulphonylureas

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 2940 participants
  Very low

Metformin vs thiazolidinediones

It is very uncertain whether summary of findings of metformin monotherapy for adults with type 2… changes cardiovascular mortality (CVM) compared with thiazolidinediones (very low certainty).

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  RR 0.71 [0.21, 2.39]
  4 studies · 3211 participants
  Very low

Metformin vs dipeptidyl‐peptidase 4 inhibitors

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1206 participants
  Very low

Metformin vs glucagon like peptide‐1 analogues

• Metformin monotherapy for adults with type 2 diabetes mellitus 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 807 participants
  Very low