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Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4 questions · 5 findings · 4 reviews · Metabolic and Endocrine Disorders

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No studies found 1 · 20%GRADE not reported 0 · 0%Very low 2 · 40%Low 1 · 20%Moderate 1 · 20%High 0 · 0%

Intervention not reported

Cardiovascular mortality a. Intervention vs placebo [30 weeks to 4.75 years] b. Intervention vs insulin [4.75 years to 10.0 years] · participants with type 2 diabetes mellitus

The intervention may leads to higher cardiovascular mortality a. Intervention vs placebo [30 weeks to… (low certainty).

1 finding from 1 review

Summary of findings: pioglitazone monotherapy vs placebo

Cardiovascular mortality · people at increased risk for developing type 2 diabetes

It is very uncertain whether summary of findings: pioglitazone monotherapy changes cardiovascular mortality (N) compared with placebo (very low certainty).

1 finding from 1 review