What do systematic reviews say?

Diet vs physical activity or standard treatment

• Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 530 participants
  Very low

Summary of findings table for metformin plus intensive diet and exercise vs intensive diet and exercise

The review found no eligible studies for this question.

• Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Adverse event outcomes for dietary combined with physical activity interventions vs usual care

It is very uncertain whether diet plus physical activity changes cardiovascular mortality compared with standard treatment (very low certainty).

• Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications… 2017 · Cochrane Headline outcomes only
  RR 0.94 [0.24, 3.65]
  7 studies · 3263 participants
  Very low

Metformin vs diet and exercise or another antidiabetic drug

The review found no eligible studies for this question.

• Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Physical activity vs usual care

• Diet, physical activity or both for prevention or delay of type 2 diabetes mellitus and its associated complications… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 274 participants
  Very low