What do systematic reviews say?

Resin-modified glass ionomer cement for bonding orthodontic brackets vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control

A single multicenter RCT found resin-modified glass-ionomer cement did not reduce new white spot lesions or bond failures versus conventional composite (ungraded).

• Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed Orthodontic… 2024 All outcomes

  During fixed appliance treatment · Orthodontic clinical practice (in-vivo human clinical trials); adolescents and adults
  Benson 2019 (1 multicenter single-blind RCT, 197 patients): no difference in the proportion of patients with new WSLs or first-time bracket failures between RM-GIC and resin adhesive (p>0.05). No meta-analysis performed.
  1 study · 197 participants
  GRADE not reported

Chemical cured composite vs Light cured composite

• Adhesives for fixed orthodontic brackets 2018 · Cochrane All outcomes

  To end of appliance treatment
  Additional Table 1 summarises the proportion of bracket failures for a CC and LC composite with two different bracket bases (O'Brien 1989). The paper reported the results of applying a Mantel-Haenszel Chi2 test which…
  1 study · 52 participants
  GRADE not reported

Chemical cured composite vs Glass ionomer cement (GIC)

• Adhesives for fixed orthodontic brackets 2018 · Cochrane All outcomes

  To end of appliance treatment
  The one trial article for this adhesive comparison reported the results of paired t-tests comparing different sides of the mouth. No standard deviations were presented, so we were unable to reproduce the data. The…
  1 study · 60 participants
  GRADE not reported

Chemical cured composite vs Light-cured compomer (polyacid-modified composite resin)

Chemical cured composite showed no clear difference in bracket (bond) failure compared with compomer (polyacid-modified resin composite); GRADE not reported.

• Adhesives for fixed orthodontic brackets 2018 · Cochrane All outcomes

  To end of appliance treatment
  OR 0.86 [0.24, 2.98]
  1 study · 45 participants
  GRADE not reported