Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 50%Low 0 · 0%Moderate 1 · 50%High 0 · 0%

Human activated protein C vs heparin

Bleeding · DIC

It is very uncertain whether human activated protein C changes bleeding compared with heparin (very low certainty).

1 finding from 1 review

Treatment for disseminated intravascular coagulation in patients with acute and chronic leukemia 2015 · Cochrane Headline outcomes only
RR 0.06 [0, 1.09]
1 study · 132 participants
Very low

Human recombinant activated protein C vs placebo

Serious bleeding events in adult and paediatric patients (days 0 to 28) · patients with severe sepsis or septic shock

Human recombinant activated protein C probably leads to higher serious bleeding events in adult and paediatric patients (days 0 to… compared with placebo (moderate certainty).

1 finding from 1 review

Human recombinant protein C for severe sepsis and septic shock in adult and paediatric patients 2012 · Cochrane Headline outcomes only
RR 1.45 [1.08, 1.94]
6 studies · 6767 participants
Moderate