Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

13 questions · 19 findings · 3 reviews · Gynaecology and Fertility

No studies found 1 · 5.3%GRADE not reported 0 · 0%Very low 10 · 52.6%Low 8 · 42.1%Moderate 0 · 0%High 0 · 0%

Metformin vs clomiphene

Ovulation rate per woman fParticipants with BMI < 30 kg/m2 · women with polycystic ovary syndrome

Metformin showed no clear difference in ovulation rate per woman fParticipants with BMI < 30 kg/m2 compared with clomiphene citrate (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin vs clomiphene

Ovulation rate per woman fParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome

Metformin may leads to lower ovulation rate per woman fParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin vs clomiphene

Live birth rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome

It is very uncertain whether metformin changes live birth rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (very low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin vs clomiphene

Clinical pregnancy rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome

Metformin may leads to lower clinical pregnancy rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin vs clomiphene

Live birth rate per woman aParticipants with BMI < 30 kg/m2 or ≤ 32 kg/m2 · women with polycystic ovary syndrome

It is very uncertain whether metformin changes live birth rate per woman aParticipants with BMI < 30 kg/m2 or ≤ 32… compared with clomiphene citrate (very low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin vs clomiphene

Clinical pregnancy rate per woman Participants with BMI < 30 kg/m2 or ≤ 32 kg/m2a · women with polycystic ovary syndrome

Metformin may leads to higher clinical pregnancy rate per womanaParticipants with BMI < 30 kg/m2… compared with clomiphene citrate (low certainty).

2 findings from 2 reviews · compare the 2 reviews