What do systematic reviews say?

Topical metronidazole vs oral (oxy)tetracycline

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 258 participants
  Low

Azelaic acid vs placebo

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 1245 participants
  High

Azelaic acid vs topical metronidazole

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 491 participants
  Low

Metronidazole vs placebo

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 602 participants
  Moderate

Clindamycin phosphate 1.2% + tretinoin 0.025% gel vs placebo

Clindamycin phosphate 1.2% + tretinoin 0.025% gel showed no clear difference in assessment of erythema or telangiectasia compared with placebo (moderate certainty).

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  RR 1.71 [0.7, 4.18]
  1 study · 83 participants
  Moderate

Tetracycline vs placebo

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 39 participants
  Moderate

Topical ivermectin vs placebo

The review found no eligible studies for this question.

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Topical ivermectin vs topical metronidazole

The review found no eligible studies for this question.

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Ciclosporin ophthalmic emulsion 0.05% vs artificial tears

The review found no eligible studies for this question.

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Azithromycin vs doxycycline

The review found no eligible studies for this question.

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Low dose isotretinoin 0.3 mg/kg vs doxycycline

Low dose isotretinoin 0.3 mg/kg showed no clear difference in assessment of erythema or telangiectasia Improved or healed compared with doxycycline 50‐100 mg (high certainty).

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  RR 0.94 [0.83, 1.08]
  1 study · 285 participants
  High

Pulsed dye laser vs intense pulsed light therapy

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 40 participants
  Moderate

Doxycycline 40 mg + metronidazole 1% gel vs doxycycline 100 mg + metronidazole 1% gel

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 91 participants
  Low

Pulsed dye laser vs Nd:YAG laser

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 14 participants
  Low

Doxycycline 40 mg vs placebo

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 537 participants
  High

Topical brimonidine vs vehicle

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 553 participants
  High

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

• Interventions for rosacea 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 60 participants
  Low