Antibacterial S. mutans reduction only in Farzanegan (chitosan+TiO2); Mollabashi (TiO2-only) showed no significant antibacterial effect - not attributable to TiO2 alone vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control
Streptococcus mutans count · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
The antibacterial (S. mutans) effect of TiO2 nanoparticles was conflicting across two RCTs (ungraded).
1 finding from 1 review
- Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed Orthodontic… 2024 All outcomes1 day to 6 months · Orthodontic clinical practice (in-vivo human clinical trials); adolescents and adults · Antibacterial (S. mutans)Two RCTs gave conflicting antibacterial results: Farzanegan 2021 reported a significant decrease in S. mutans with the chitosan plus TiO2 adhesive (p=0.01 lateral incisors; p=0.001 second premolars); Mollabashi 2022…2 studies · 64 participantsGRADE not reported