Sildenafil vs placebo
All‐cause mortality · pulmonary hypertension in neonates
Sildenafil may leads to lower all‐cause mortality compared with placebo (low certainty).
1 finding from 1 review
- RR 0.2 [0.07, 0.56]3 studies · 77 participantsLow
Findings
What do systematic reviews say?
4 questions · 4 findings · 2 reviews · Neonatal
No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 50%Low 2 · 50%Moderate 0 · 0%High 0 · 0%
Sildenafil vs active control
All‐cause mortality · pulmonary hypertension in neonates
It is very uncertain whether sildenafil changes all‐cause mortality compared with active control (very low certainty).
1 finding from 1 review
- RR 0.55 [0.05, 5.75]1 study · 65 participantsVery low
Sildenafil plus iNO vs placebo plus iNO
All‐cause mortality · pulmonary hypertension in neonates
Sildenafil plus iNO showed no clear difference in all‐cause mortality compared with placebo plus iNO (low certainty).
1 finding from 1 review
- RR 1.27 [0.26, 6.28]1 study · 24 participantsLow
Summary of findings table ‐ Silicone earplugs vs no earplugs
All‐cause mortality during hospital stay · preterm or very low birth weight infants
It is very uncertain whether summary of findings table ‐ Silicone earplugs changes all‐cause mortality during hospital stay compared with no earplugs (very low certainty).
1 finding from 1 review
- Noise or sound management in the neonatal intensive care unit for preterm or very low birth weight infants 2024 · Cochrane Headline outcomes onlyRR 2.07 [0.64, 6.7]1 study · 34 participantsVery low